Modified forms of low-density lipoprotein and atherosclerosis
نویسندگان
چکیده
منابع مشابه
Phospholipase D-modified Low Density Lipoprotein
Macrophage uptake of modified forms ofLDL leads to cellular cholesterol accumulation. Upon incubation of LDL with phospholipase D (PLase D), a timeand enzyme dose-dependent production of phosphatidic acid (PA), paralleled by a rapid reduction in LDL phosphatidyl choline content (up to 65% within 15 min of incubation) was noted. No lipid peroxidation could be found in PLase D-modified LDL. Upon ...
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OBJECTIVE Atherosclerosis is associated with immune responses to oxidized low-density lipoprotein (oxLDL). The presence of activated macrophages and T cells in lesions suggests that cell-mediated immune reactions are taking place during the disease process. However, the role of specific immune responses has remained unclear. We have previously shown that transfer of CD4+ T cells from apolipopro...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 1993
ISSN: 0954-6820,1365-2796
DOI: 10.1111/j.1365-2796.1993.tb00980.x